Genetic Factor(s) Influence Scar Formation in Experimental Pyelonephritis

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Genetic factor(s) influence scar formation in experimental pyelonephritis.

Two inbred strains of rat have been identified that show markedly different responses to experimentally induced renal infection. Experiments involving these two strains and their F1 progeny have shown that a genetic factor either protects the host from a tissue-destructive inflammatory response (autosomal dominant gene) or potentiates lesion formation (autosomal recessive gene). The data are th...

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Every Other Day Gentamicin Injection in Experimental Pyelonephritis in Rats: Risk of Scar Formation

Background: Urinary tract infection in children may cause renal scar formation, which can be prevented by early and appropriate treatment. Recent studies showed that single daily injection of gentamycin can produce best effect without increasing the side effects. The aim of this study was to evaluate the rate of renal scar formation when new regime (every other day gentamicin injection) used fo...

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every other day gentamicin injection in experimental pyelonephritis in rats: risk of scar formation

background: urinary tract infection in children may cause renal scar formation, which can be prevented by early and appropriate treatment. recent studies showed that single daily injection of gentamycin can produce best effect without increasing the side effects. the aim of this study was to evaluate the rate of renal scar formation when new regime (every other day gentamicin injection) used fo...

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Experimental Pyelonephritis

Uncomplicated pyelonephritis in man is almost always produced by a single species of bacteria, ordinarily a Gram-negative organism. Mixed infection of the urinary tract is usually associated with chronic obstruction or instrumentation. In animals the production of pyelonephritis results in an acute process, and in most models a single species of bacteria has been used as the infecting agent. It...

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ژورنال

عنوان ژورنال: Nephron

سال: 1985

ISSN: 1660-8151,2235-3186

DOI: 10.1159/000183497